- Chancres appear 21 days after sexual contact with an infected person; On the vulva, cervix (female); On the penis(male)
- Primary lesion is circular, indurated with an eroded base
- Marked edema of the surrounding tissues
- Superficial inguinal lymphadenopathy
- Generalized skin eruptions
- Papulo-squamous lesions
- Flat, warty-looking growths (vulva –female and around anus -both sexes)
- White patches on the tongue or roof of the mouth.
- Patchy hair loss.
- Lesions my form large plaques and are highly infectious
Latent and tertiary stages
Gummatous lesion of skin/mucous membrane (rarely seen on genitalia)
- Tabes dorsalis
- Aortic incompetence
- Immune-flouroscent technique
- Flouroscent treponemal antibody absorption test(FTA)
- Complement fixation(Wassermann)
- Spinal fluid test (neurosyphilis)
Damage done to body organs cannot be reversed.