Chronic myeloid leukemia

Chronic Myelogenous Leukemia (CML) can be called chronic granulocytic leukemia or chronic myeloid leukemia. It is a cancer of the bone marrow, the spongy tissues in the bone responsible for producing blood cells. CML affects myeloid cells and usually grows slowly at first.

Causes–

  • Genetic Mutation- The mutations in the DNA causes the stem cells to produce more white blood cells too quickly
  • Reduction in the blood cells other than WBC’s
  • Exposure to radiation-nuclear disaster, treatment of a previous cancer(thyroid cancer or Hodgkin’s lymphoma), chemical benzene
  • Exposure to pesticides.

Symptoms And Signs–

  • Chronic Phase—

This phase lasts for months or years with few or no symptoms

  • Accelerated Phase–

This is a dangerous phase with few symptoms like-

  1. Fever (without infection)
  2. Bone pain
  3. An enlarged spleen
  • Blast crisis-

Untreated CML progresses to the blast crisis phase with the following symptoms:-

  1. Bleeding and bruising
  2. Fatigue
  3. Infections
  4. Low-grade fever
  5. Night sweats
  6. Petechiae
  7. Pressure under the left ribs from a swollen spleen
  8. Weakness

Investigations—

  • Bone marrow aspiration
  • Biopsy
  • Full blood count with white blood cell differential
  • Chromosomal study

Treatment—

  • Early-stage chronic myeloid leukaemia

Medicines

  • Advanced chronic myeloid leukaemia
  1. Chemotherapy
  2. Bone marrow and stem cell transplants-Transplantations have better outcomes if the donor has the same tissue type as the person who is receiving the donation. The best candidate to provide a donation is usually a brother or sister with the same tissue type.

Complications—-

  • Diarrhoea
  • High fever of 38 C (101.4 F) or above
  • Infertility
  • Recurrent infections

3 thoughts on “Chronic myeloid leukemia”

  1. I’m amazed, I have to admit. Rarely do I come across a blog that’s equally educative and entertaining, and let me tell you, you’ve hit the nail on the head. The problem is an issue that too few men and women are speaking intelligently about. I’m very happy that I came across this in my search for something concerning this.

  2. Im impressed, I must say. Really seldom do I see a blog thats both educational and entertaining, and let me tell you, youve hit the nail on the head. Your opinion is outstanding; the matter is something that not enough people are speaking intelligently about. Im really happy that I stumbled across this in my search for something relating to this.

Leave a Comment