Chronic Lymphoid Leukemia

CLL affects lymphoid cells and usually grows slowly.  It almost never affects children.

Causes—-

Cause is unknown. There is no link to radiation, cancer-causing chemicals, or viruses.

CLL primarily affects adults. The disease is more common in Jewish people of Russian or East European descent, and is uncommon in Asians.

Symptoms And Signs–

  • Breathlessness
  • Early satiety
  • Loss of appetite
  • Night sweats
  • Repeated infections
  • Swollen lymph nodes
  • Swollen spleen
  • Tiredness
  • Unintentional weight loss
  • Unusual bleeding and bruising
  • Weakness

Investigations—

  • Full blood count
  • Bone marrow biopsy
  • CT scan-Abdomen,chest,pelvis
  • Flow cytometry
  • Serum immunoglobin level
  • Serum lactate dehydrogenase (LDH) level

Treatment—-

  • Chemotherapy
  • Radiation(rarely used)
  • Blood transfusion
  • Bone marrow or stem cell transplantation

Complications—-

  • Autoimmune hemolytic anemia
  • Hypogammaglobulinemia
  • Idiopathic thrombocytopenic purpura (ITP)
  • Other cancers
  • Side effects of chemotherapy

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